In the Naltrexone for Overdose Prevention (NOD) study, we want to see if naltrexone can prevent fentanyl overdoses in people who use other drugs (like methamphetamine or cocaine). In this study, all participants will receive harm reduction materials, such as new needles or pipes. Half of study participants will also receive the study medication.

Naltrexone is an FDA-approved medication that has been used for over 15 years to treat opioid use disorder.

Great question! While someone may not intentionally use fentanyl, it's being found in various drug supplies and leading to unintentional overdoses. Naltrexone works as an opioid blocker on certain receptors in the brain. We are investigating if injectable naltrexone can help to prevent accidental overdose for people who use stimulants, such as methamphetamine and cocaine.  

In this study, half (50%) of participants will be randomly selected to receive the study medication naltrexone. Participants who are in the study medication group will receive an injection of naltrexone about once a month (every 4 weeks) for 6 months.

To see if you may be eligible to participate, call us at 628.217.6319 or send us your information using the contact form below. Someone from our team will contact you to see if you may be eligible to come into our office. If you are, we will set up your first screening visit.

The screening process can take up to 4 weeks to determine if you are eligible to participate. This process includes meeting with a research associate, clinical staff and other study procedures, which will be explained to you during the informed consent process.

If you are eligible and choose to participate, you will be asked to come to our office at 25 Van Ness Ave. about 7 times over 6 months. Study visits will include meeting with a research associate and nurse, answering survey questions, having your blood and other samples taken, receiving harm reduction supplies, and for half of participants receiving the study medication injection. 

Yes, you will be compensated for your time and effort. If you are eligible and complete all study procedures, you may earn up to $425 over the course of the study.